Elucidating the mechanism of cellular uptake dating valco amplifiers

In this article, we briefly review the endocytic pathways used by cells, pointing out their defining characteristics and highlighting physical limitations that may direct the internalization of nanoparticles to a subset of these pathways.A more detailed description of these pathways is presented in the literature.Next, we briefly review some of the important nanomedicines already on the market or in clinical development that serve to exemplify how endocytosis can be exploited for medical benefit.

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Inherent in this concept is the recognition that nanosized features offer certain advantageous properties, and one of the most widely exploited of these properties is the ability to gain cellular entry through endocytosis.Endocytosis has an important role in diagnostics, allowing for the selective uptake and labeling of cells by various medical imaging agents (e.g., as contrast agents for identifying cancerous lesions by MRI).Increased target selectivity leads to improved potency and/or decreased toxicity, resulting in an overall improved therapeutic index.In other applications, endocytosis is exploited to fundamentally enable drug activity.

Nanomedicines are increasingly becoming a part of our medical armament to diagnose and treat disease.The term “nanomedicine” often refers to the use of various nanotechnology strategies for medical applications.

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