Faris has played Christy Plunkett on the CBS sitcom Mom since 2013.
The show has earned the actress further critical and popular acclaim and two People's Choice Award nominations.
Faris has said in interviews she often imagined her retainer talking to her, remarking that she would picture herself "on talk shows to talk about [her] talking retainer".
During the early to mid-2000s, she played supporting roles in dramatic pictures such as Lost in Translation (2003) and Brokeback Mountain (2005), and appeared in various comedies, including The Hot Chick (2002), Waiting...(2005), Just Friends (2005), and My Super Ex-Girlfriend (2006).She received critical praise for her role in the indie black comedy Smiley Face (2007) and then starred in the Playboy-themed movie The House Bunny (2008) which was billed as her star vehicle and earned her an MTV Movie Award nomination for Best Comedic Performance.In 2009, she co-appeared in Frequently Asked Questions About Time Travel and Observe and Report, and also had voice-over roles in Cloudy with a Chance of Meatballs and Alvin and the Chipmunks: The Squeakquel (she has continued to lend her voice for both films' sequels).
She starred and co-produced the feature What's Your Number?(2011), which was followed by roles in the political satire The Dictator (2012), and the romantic comedy I Give It a Year (2013).