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Nationwide, at least 45 million people ages 12 and older, or one out of five adolescents and adults, have had genital HSV infection.Between the late 1970s and the early 1990s, the number of Americans with genital herpes infection increased 30 percent.Typically, another outbreak can appear weeks or months after the first, but it almost always is less severe and shorter than the first outbreak.

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Genital HSV-2 infection is more common in women (approximately one out of four women) than in men (almost one out of five).This may be due to male-to-female transmissions being more likely than female-to-male transmission. HSV-1 and HSV-2 can be found in and released from the sores that the viruses cause, but they also are released between outbreaks from skin that does not appear to be broken or to have a sore.

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